The Innovation Commission promotes innovation development and scaling at the intersection of climate change, food security, and agriculture. The Commission identifies high return investments in innovation for climate mitigation and adaptation in agriculture and food security. In many cases, even once innovations have been developed, market or government failures prevent them from reaching an efficient scale. The Commission identifies such barriers and proposes institutional mechanisms to efficiently stimulate innovation and take the most effective ones to scale. It also examines the role of meta-innovations: mechanisms for encouraging innovation development and scaling, such as open, tiered, evidence-based social innovation funds, and Advance Market Commitments for climate change, food security, and agriculture.